In a large skillet over medium heat, add the ground beef and season with garlic powder, onion powder, Worcestershire sauce, salt, and pepper. Cook until browned and cooked through, about 7-10 minutes.

In a mixing bowl, combine mayonnaise, dill relish, yellow mustard, ketchup, white vinegar, smoked paprika, and sugar. Whisk until smooth and adjust the flavors to your liking.

In a serving bowl, layer chopped iceberg lettuce, shredded cheddar cheese, halved cherry tomatoes, and sliced pickles. Add the cooked ground beef and mix.

Drizzle the dressing over the salad and toss gently to coat. Top with toasted sesame seeds before serving.