As the evening sun sets, filling my kitchen with soft golden light, I often find myself craving a dish that warms both body and soul. Enter my High-Protein Spinach and Artichoke Chicken Casserole, a delightful combination of tender chicken, creamy spinach, and artichokes that’s as nourishing as it is comforting. This easy-to-make casserole is your secret weapon for busy weeknights because it packs in protein while delivering that cozy, home-cooked vibe. Plus, it comes together with minimal cleanup, so you can spend more time enjoying your meal instead of being stuck at the sink. Are you ready to make your new favorite weeknight dinner? Let’s dive in!

Why is this casserole a must-try?
Comforting, hearty goodness: This casserole combines tender chicken with a creamy spinach and artichoke mix that will satisfy your cravings.
High-protein delight: Packed with protein, it’s perfect for health-conscious eaters looking to fuel their bodies.
Easy prep: The straightforward process makes it a breeze for even the busiest weeknights—seriously, minimal cleanup!
Versatile flavors: You can easily tailor it to your taste by swapping in different cheeses or adding a spicy kick, just like in my Buffalo Chicken Mac.
Family favorite: Whether you serve it at dinner or as a potluck hero, everyone will be asking for seconds! Don’t forget to pair it with a side salad or some crusty bread for a complete meal.
Spinach and Artichoke Chicken Casserole Ingredients
• For the Casserole
- Chicken Breasts – Lean protein source; using cooked, shredded chicken makes this dish come together quickly.
- Fresh Baby Spinach – Adds vibrant color and essential nutrients; feel free to substitute kale for a twist, but it may need extra seasoning.
- Artichoke Hearts – Unique flavor and texture; canned artichokes are convenient, just ensure they’re well-drained.
- Non-Fat Greek Yogurt – Provides creaminess while keeping it healthy; if you prefer a richer taste, substitute with full-fat yogurt.
- Light Cream Cheese – Enhances creaminess and helps bind everything together; regular cream cheese can be used for a more indulgent option.
- Shredded Mozzarella Cheese – Delivers that melty, gooey goodness; other melting cheeses like cheddar are also great alternatives.
- Grated Parmesan Cheese – Adds delectable umami flavor; feel free to omit for a lighter dish or use nutritional yeast for a vegan alternative.
- Garlic – Packs a punch of flavor; fresh garlic is always best, but powdered garlic works in a pinch.
- Salt & Ground Black Pepper – Essential for seasoning; adjust according to your dietary needs for perfect flavor balance.
Step‑by‑Step Instructions for Spinach and Artichoke Chicken Casserole
Step 1: Preheat and Prepare
Preheat your oven to 375°F (190°C). While your oven heats up, grab a casserole dish and grease it lightly with cooking spray or butter to prevent sticking. This preparation will ensure your Spinach and Artichoke Chicken Casserole is easy to serve and looks beautiful once baked.
Step 2: Mix the Base
In a large mixing bowl, combine 1 cup of non-fat Greek yogurt, 4 ounces of light cream cheese, minced garlic, salt, and black pepper. Using a hand mixer or a sturdy spatula, blend until the mixture is smooth and creamy, which should take about 1-2 minutes. This mixture will provide a luscious base for your casserole.
Step 3: Incorporate the Goodness
Fold in 2 cups of shredded cooked chicken, 2 cups of fresh baby spinach, 1 cup of drained artichoke hearts, and half of the shredded mozzarella cheese (about 1 cup). Gently mix until everything is evenly combined, ensuring the spinach and artichokes are well distributed throughout. The vibrant colors should make you eager to dive in!
Step 4: Assemble the Casserole
Transfer the chicken and spinach mixture into the prepared casserole dish, spreading it evenly with a spatula. Top with the remaining shredded mozzarella and sprinkle ¼ cup of grated Parmesan cheese over the top. This cheesy layer will form a deliciously golden crust as it bakes to perfection.
Step 5: Bake to Perfection
Place the assembled casserole into the preheated oven and bake for 30-35 minutes. Keep an eye on your dish; you’re looking for bubbly edges and a beautifully golden cheese topping that signals it’s ready. The aroma of melted cheese and savory goodness will fill your kitchen!
Step 6: Cool and Serve
Once baked, carefully remove the Spinach and Artichoke Chicken Casserole from the oven and let it cool for about 5 minutes. This cooling period allows the casserole to set a bit for easier serving. Scoop out generous portions and enjoy this comforting dish with family or friends!

How to Store and Freeze Spinach and Artichoke Chicken Casserole
Fridge: Keep leftovers in an airtight container for up to 3 days. This will maintain the casserole’s creamy texture and prevent it from drying out.
Freezer: Portion the casserole into freezer-safe containers and store for up to 3 months. Wrap tightly to avoid freezer burn.
Reheating: For the best results, reheat in the oven at 350°F (175°C) until warmed through, about 20-25 minutes. This will keep it bubbly and delicious, just like when it was freshly made.
What to Serve with High-Protein Spinach and Artichoke Chicken Casserole
As you prepare this mouthwatering casserole, consider pairing it with delightful sides that elevate your dining experience.
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Garlic Bread: Crunchy on the outside and soft on the inside, garlic bread is a perfect companion to scoop up the creamy casserole goodness. It brings that irresistible aroma and flavor that transforms your meal into a comforting feast.
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Simple Green Salad: A fresh salad with mixed greens and a light vinaigrette adds a vibrant splash of color and crunch. The crispness complements the creamy texture of the casserole beautifully, creating balance on your plate.
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Roasted Vegetables: Toss seasonal vegetables in olive oil and roast them until caramelized. Their smoky, sweet flavors enhance the dish while offering a nutritious element that rounds out your meal.
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Quinoa Pilaf: Fluffy quinoa cooked with herbs offers a delightful, nutty flavor. It’s a high-protein side that mirrors the casserole’s profile, making every bite feel wholesome and satisfying.
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Sweet Potato Mash: Creamy, slightly sweet mashed sweet potatoes provide a warm contrast to the savory casserole. Their natural sweetness and rich texture can make every mouthful an uplifting experience.
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Chilled White Wine: A crisp Sauvignon Blanc or Chardonnay brings a refreshing element to balance the richness of the casserole. Sipping on a glass as you enjoy your meal is just the icing on the cake!
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Lemon Sorbet: For dessert, a light lemon sorbet cleanses the palate after your hearty meal. Its bright, zesty flavor provides a refreshing finishing touch everyone will love.
Spinach and Artichoke Chicken Casserole Variations
Feel free to get creative with your casserole and make it your own—there’s so much room for delicious tweaks!
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Kale Substitute: Swap fresh baby spinach for kale to add a heartier texture. Just remember to season a bit more for flavor!
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Add a Kick: Toss in some hot sauce or spicy peppers for a delightful kick that’ll awaken your taste buds and transform the dish.
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Cheese Variety: Experiment with different cheeses, such as gouda or pepper jack, to give your casserole a new flavor profile with every bite!
Imagine pairing it with the creamy goodness of Honey Pepper Chicken for an unforgettable feast!
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Extra Veggies: Sneak in some chopped bell peppers or zucchini for added nutrients and texture. It’s a great way to clean out your fridge too!
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Herbal Infusion: Fresh herbs like thyme or basil can elevate the dish with a pop of vibrant aroma. Try adding them right into the mix for an aromatic twist.
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Dairy-Free Delight: Use coconut yogurt and a dairy-free cream cheese as substitutes to make this a deliciously creamy yet dairy-free option.
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Protein Boost: Add cooked quinoa or black beans for an extra protein hit and to enhance heartiness without overwhelming the casserole base.
The variations are endless! Feel free to explore other avenues, such as incorporating your favorite veggies or spices. For more delightful inspirations, you might enjoy my Chicken Stuffing Casserole.
Expert Tips for Spinach and Artichoke Chicken Casserole
• Creaminess Boost: Adding a splash of milk or broth to the yogurt mixture can enhance the creaminess of your casserole without compromising its health benefits.
• Perfect Baking: Keep an eye on cooking time! Overbaking can lead to dry texture. Look for that beautiful golden cheese crust and bubbling edges for the ideal Spinach and Artichoke Chicken Casserole.
• Leftovers Lifesaver: Your leftovers can last up to 3 days in the fridge. Reheat them in the oven for optimal texture; microwaving can make them rubbery.
• Flavor Variations: Feel free to add hot sauce if you enjoy some spice! This will elevate the dish and provide a delightful twist to the classic recipe.
• Ingredient Prep: For easier mixing, shred your chicken ahead of time or use rotisserie chicken. It saves valuable prep time during busy evenings!
Make Ahead Options
These High-Protein Spinach and Artichoke Chicken Casserole is a fantastic choice for meal prep! You can assemble the entire casserole up to 24 hours in advance, covering it tightly with plastic wrap or aluminum foil to prevent drying out. To maintain the quality, refrigerate it as soon as you finish assembling. When you’re ready to enjoy, simply remove the cover and bake directly from the fridge, adding an extra 5-10 minutes to the cooking time to ensure it’s heated through. This way, you’ll have a delicious, comforting meal on the table with minimal effort, perfect for those busy weeknights!

Spinach and Artichoke Chicken Casserole Recipe FAQs
What type of spinach should I use?
Fresh baby spinach works best in this dish as it adds vibrant color and essential nutrients. If you prefer, you can substitute it with kale, but be aware that kale may require additional seasoning to enhance its flavor.
How should I store leftovers?
Leftovers can be kept in an airtight container in the fridge for up to 3 days. This will help maintain the casserole’s creamy texture and prevent it from drying out. When reheating, I recommend using the oven to keep it bubbly and delicious.
Can I freeze the casserole?
Absolutely! You can freeze the assembled casserole for up to 3 months. Portion it into freezer-safe containers, and make sure to wrap them tightly to avoid freezer burn. To reheat, bake at 350°F (175°C) until warmed through, about 20-25 minutes.
What if my casserole turns out dry?
If your casserole becomes dry, it might be due to overbaking. Always keep an eye on it while it bakes and look for a golden cheese crust along with bubbling edges—these are signs it’s perfectly cooked. To revive leftovers, I suggest adding a splash of broth before reheating to bring back some moisture.
Is this recipe suitable for someone with dairy allergies?
For those with dairy allergies, you can make this casserole dairy-free by using plant-based yogurt and cream cheese alternatives. Additionally, substitute nutritional yeast for parmesan cheese to get that savory flavor without dairy. Always check ingredient labels to ensure they meet your dietary needs.

Delicious Spinach and Artichoke Chicken Casserole Made Easy
Ingredients
Equipment
Method
- Preheat your oven to 375°F (190°C) and grease a casserole dish.
- In a large mixing bowl, combine Greek yogurt, cream cheese, minced garlic, salt, and pepper. Mix until smooth.
- Fold in shredded chicken, spinach, artichoke hearts, and half of the mozzarella cheese. Mix until combined.
- Transfer the mixture to a casserole dish and top with remaining mozzarella and grated Parmesan cheese.
- Bake for 30-35 minutes until bubbly and golden on top.
- Let cool for 5 minutes before serving.

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